Indocyanine green is a medically useful dye that absorbs and fluoresces in the near infrared and has been sporadically employed clinically as an optical tracer agent for liver function evaluation and cardiac output measurements. The poor stability of this dye in aqueous solution, especially at the high concentrations needed for bolus injection, has been a hindrance in clinical application. However, by using carefully chosen macromolecular additives, the stability of these aqueous dye solutions may be enhanced significantly. Such noncovalent binding between dye and carrier molecules was found to preserve substantially the dye in aqueous solutions for several weeks with no apparent changes in the measured in vivo biological properties.
How to translate text using browser tools
1 March 2000
Stabilization of the Optical Tracer Agent Indocyanine Green Using Noncovalent Interactions
Raghavan Rajagopalan,
Pamela Uetrecht,
Joseph E. Bugaj,
Samuel A. Achilefu,
Richard B. Dorshow
ACCESS THE FULL ARTICLE
It is not available for individual sale.
This article is only available to subscribers.
It is not available for individual sale.
It is not available for individual sale.
Photochemistry and Photobiology
Vol. 71 • No. 3
March 2000
Vol. 71 • No. 3
March 2000